Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo.
Yang M, Woolfenden HC, Zhang Y, Fang X, Liu Q, Vigh ML, Cheema J, Yang X, Norris M, Yu S, Carbonell A, Brodersen P, Wang J, Ding Y. Nucleic Acids Res. 2020 Jul 11:gkaa577. Pubmed
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
Barbier-Torres L, Fortner KA, Iruzubieta P, Delgado TC, Giddings E, Chen Y, Champagne D, Fernández-Ramos D, Mestre D, Gomez-Santos B, Varela-Rey M, de Juan VG, Fernández-Tussy P, Zubiete-Franco I, García-Monzón C, González-Rodríguez Á, Oza D, Valença-Pereira F, Fang Q, Crespo J, Aspichueta P, Tremblay F, ...
mRNA structural dynamics shape Argonaute-target interactions.
Ruijtenberg S, Sonneveld S, Cui TJ, Logister I, de Steenwinkel D, Xiao Y, MacRae IJ, Joo C, Tanenbaum ME. Nat Struct Mol Biol. 2020 Jul 13. Pubmed
The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Biscans A, Caiazzi J, Davis S, McHugh N, Sousa J, Khvorova A. Nucleic Acids Res. 2020 Jul 16 Pubmed
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. Neuron. 2020 Jul 8:S0896-6273(20)30481-5. Pubmed
Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease
Elitt MS, Barbar L, Shick HE, Powers BE, Maeno-Hikichi Y, Madhavan M, Allan KC, Nawash BS, Gevorgyan AS, Hung S, Nevin ZS, Olsen HE, Hitomi M, Schlatzer DM, Zhao HT, Swayze A, LePage DF, Jiang W, Conlon RA, Rigo F, Tesar PJ. Nature. 2020 Jul ...
Therapeutic siRNA: state of the art
Hu B, Zhong L, Weng Y, Peng L, Huang Y, Zhao Y, Liang XJ. Signal Transduct Target Ther. 2020 Jun 19;5(1):101. Pubmed
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
Debacker AJ, Voutila J, Catley M, Blakey D, Habib N. Mol Ther. 2020 Jun 17:S1525-0016(20)30305-1. Pubmed
Phosphorothioate modified oligonucleotide-protein interactions
Crooke ST, Vickers TA, Liang XH. Nucleic Acids Res. 2020 Jun 4;48(10):5235-5253. Pubmed
Rational design of aptamer switches with programmable pH response
Thompson IAP, Zheng L, Eisenstein M, Soh HT. Nat Commun. 2020 Jun 10;11(1):2946. Pubmed