Flash Synthesis of Spherical Nucleic Acids with Record DNA Density
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery
Munson MJ, O'Driscoll G, Silva AM, LĂ¡zaro-IbĂ¡Ă±ez E, Gallud A, Wilson JT, CollĂ©n A, Esbjörner EK, Sabirsh A. Commun Biol. 2021 Feb 16;4(1):211. Pubmed
Centyrin ligands for extrahepatic delivery of siRNA.
Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Mol Ther. 2021 Feb 15:S1525-0016(21)00082-4. Pubmed
siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M. Nucleic Acids Res. 2021 Feb 12 Pubmed
Perspectives on the Designation of Oligonucleotide Starting Materials
Kiesman WF, McPherson AK, Diorazio LJ, Van den Bergh L, Smith PD, Northall JM, Fettes A, Wang T, Mehlmann M, Raza S, Held G. Nucleic Acid Ther. 2021 Feb 2. Pubmed
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
Zheng F, Chen J, Zhang X, Wang Z, Chen J, Lin X, Huang H, Fu W, Liang J, Wu W, Li B, Yao H, Hu H, Song E. Nat Commun. 2021 Feb 26;12(1):1341. Pubmed
Double Controlled Release of Therapeutic RNA Modules through Injectable DNA-RNA Hybrid Hydrogel
Han S, Park Y, Kim H, Nam H, Ko O, Lee JB. ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55554-55563. Pubmed
Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
Biscans A, Caiazzi J, McHugh N, Hariharan V, Muhuri M, Khvorova A. Mol Ther. 2020 Dec 19:S1525-0016(20)30681-X. Pubmed
Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Badri P, Jiang X, Borodovsky A, Najafian N, Kim J, Clausen VA, Goel V, Habtemariam B, Robbie GJ. Clin Pharmacokinet. 2020 Oct 13.
Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders
Weingärtner A, Bethge L, Weiss L, Sternberger M, Lindholm MW. Mol Ther Nucleic Acids. 2020 Sep 4;21:242-250. Pubmed