Intracellular delivery of therapeutic antisense oligonucleotides targeting mRNA coding mitochondrial proteins by cell-penetrating peptides. Cerrato CP, Kivijärvi T, Tozzi R, Lehto T, Gestin M, Langel Ü. J Mater Chem B. 2020 Epub 2020 Nov 11. Pubmed 00
Immunogenicity Assessment of Inotersen, a 2′-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety. …………… Yu RZ, Wang Y, Norris DA, Kim TW, Narayanan P, Geary RS, Monia BP, Henry SP. Nucleic Acid Ther. 2020 Oct;30(5):265-275. Pubmed 00
Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders …………… Weingärtner A, Bethge L, Weiss L, Sternberger M, Lindholm MW. Mol Ther Nucleic Acids. 2020 Sep 4;21:242-250. Pubmed 00
Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system. …………… Sullivan JM, Mazur C, Wolf DA, Horky L, Currier N, Fitzsimmons B, Hesterman J, Pauplis R, Haller S, Powers B, Tayefeh L, DeBrosse-Serra B, Hoppin J, Kordasiewicz H, Swayze EE, Verma A. J Transl Med. 2020 Aug…