Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH
SimĂ³n J, Goikoetxea-Usandizaga N, Serrano-MaciĂ¡ M, FernĂ¡ndez-Ramos D, SĂ¡enz de Urturi D, Gruskos JJ, FernĂ¡ndez-Tussy P, Lachiondo-Ortega S, GonzĂ¡lez-Recio I, RodrĂguez-Agudo R, GutiĂ©rrez-de-Juan V, RodrĂguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, GĂ³mez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin ...
Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p.
Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender I, Haller H, Kistler AD, Dueck A, Engelhardt S, Thum T, Mueller TF, WĂ¼thrich RP, Lorenzen JM. J Am Soc Nephrol. 2021 Feb;32(2):323-341. Pubmed
Development of Prodrug Type Circular siRNA for In Vivo Knockdown by Systemic Administration
Hagiwara K, Honma M, Harumoto T, Harada K, Sawada T, Yamamoto J, Shinohara F. Nucleic Acid Ther. 2020 Dec;30(6):346-364 Pubmed
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis
Leclair NK, Brugiolo M, Urbanski L, Lawson SC, Thakar K, Yurieva M, George J, Hinson JT, Cheng A, Graveley BR, AnczukĂ³w O. Mol Cell. 2020 Nov 19;80(4):648-665.e9. Pubmed
Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA
Park MS, Sim G, Kehling AC, Nakanishi K. Proc Natl Acad Sci U S A. 2020 Oct 29:202015026 Pubmed
Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function
Liu J, Cooley BC, Akinc A, Butler J, Borodovsky A. Thromb Res. 2020 Aug 28;196:200-205. Pubmed
2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA
Davis SM, Sousa J, Vangjeli L, Hassler MR, Echeverria D, Knox E, Turanov AA, Alterman JF, Khvorova A. Mol Ther Nucleic Acids. 2020 Sep 4;21:266-277. Pubmed
Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference
Ferguson CM, Echeverria D, Hassler M, Ly S, Khvorova A. Mol Ther Nucleic Acids. 2020 Sep 4;21:384-393. Pubmed
Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC
Basiri B, Xie F, Wu B, Humphreys SC, Lade JM, Thayer MB, Yamaguchi P, Florio M, Rock BM. Mol Ther Nucleic Acids. 2020 Sep 4;21:725-736. Pubmed