Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1
Ray KK, Stoekenbroek RM, Kallend D, Leiter LA, Landmesser U, Wright RS, Wijngaard P, Kastelein JJ. Circulation. 2018 May 7. pii: CIRCULATIONAHA.118.034710. PubMed
Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study
Alagia A, Jorge AF, AviĂ±Ă³ A, Cova TFGG, Crehuet R, Grijalvo S, Pais AACC, Eritja R. Chem Sci. 2018 Jan 15;9(8):2074-2086. PubMed
Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate
Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang QC, Wang HW. Cell. 2018 May 31;173(6):1549-1550. PubMed
Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice
Tasfaout H, Lionello VM, Kretz C, Koebel P, Messaddeq N, Bitz D, Laporte J, Cowling BS. Mol Ther. 2018 Apr 4;26(4):1082-1092. PubMed
Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer’s disease
Wang P, Zheng X, Guo Q, Yang P, Pang X, Qian K, Lu W, Zhang Q, Jiang X. J Control Release. 2018 Apr 19;279:220-233. PubMed
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS; Cancer Genome Atlas Research Network, Sood AK, Gunaratne PH, Sumazin P. Cell Rep. 2018 Apr 3;23(1):297-312.e12. PubMed
Knockdown of LncRNA MALAT1 contributes to the suppression of inflammatory responses by up-regulating miR-146a in LPS-induced acute lung injury
Dai L, Zhang G, Cheng Z, Wang X, Jia L, Jing X, Wang H, Zhang R, Liu M, Jiang T, Yang Y, Yang M. Connect Tissue Res. 2018 Apr 13:1-12. PubMed
saRNAdb: Resource of small activating RNAs for up-regulating the gene expression
Dar SA, Kumar M. J Mol Biol. 2018 Apr 3. pii: S0022-2836(18)30172-4. PubMed
Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. MolTher. 2018 Mar 7;26(3):708-717. PubMed
RNA activating-double stranded RNA targeting flt-1 promoter inhibits endothelial cell proliferation through solubleFLT-1 upregulation
Choi S, Uehara H, Wu Y, Das S, Zhang X, Archer B, Carroll L, Ambati BK. PLoS One. 2018 Mar 6;13(3):e0193590. PubMed