Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling.
Han M, Wang S, Fritah S, Wang X, Zhou W, Yang N, Ni S, Huang B, Chen A, Li G, Miletic H, Thorsen F, Bjerkvig R, Li X, Wang J. Brain. 2019 Dec 31. pii: awz406. PubMed
A selective Aurora-A 5′-UTR siRNA inhibits tumor growth and metastasis.
Lai CH, Chen RY, Hsieh HP, Tsai SJ, Chang KC, Yen CJ, Huang YC, Liu YW, Lee JC, Lai YC, Hung LY, Lin BW. Cancer Lett. 2019 Dec 23;472:97-107. PubMed
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile.
Huang KW, Reebye V, Czysz K, Ciriello S, Dorman S, Reccia I, Lai HS, Peng L, Kostomitsopoulos N, Nicholls J, Habib RS, Tomalia DA, Sætrom P, Wilkes E, Cutillas P, Rossi JJ, Habib NA. Mol Ther Nucleic Acids. 2019 Nov 21;19:361-370. PubMed ...
Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Ghadge GD, Sonobe Y, Camarena A, Drigotas C, Rigo F, Ling KK, Roos RP. Neurobiol Dis. 2019 Dec 16;136:104702. PubMed
Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.
González-Duarte A, Berk JL, Quan D, Mauermann ML, Schmidt HH, Polydefkis M, Waddington-Cruz M, Ueda M, Conceição IM, Kristen AV, Coelho T, Cauquil CA, Tard C, Merkel M, Aldinc E, Chen J, Sweetser MT, Wang JJ, Adams D. J Neurol. 2019 Nov 14. PubMed ...
Pharmacokinetics of Patisiran, the First Approved RNA Interference Therapy in Patients With Hereditary Transthyretin-Mediated Amyloidosis.
Zhang X, Goel V, Robbie GJ. J Clin Pharmacol. 2019 Nov 27. PubMed
Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid-siRNA conjugates.
Salim L, Islam G, Desaulniers JP. Nucleic Acids Res. 2019 Nov 28. PubMed
Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.
Liu Z, Johnson ST, Zhang Z, Corey DR. Nucleic Acid Ther. 2019 Oct 31. . PubMed
Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target
Veiga N, Goldsmith M, Diesendruck Y, Ramishetti S, Rosenblum D, Elinav E, Behlke MA, Benhar I, Peer D. J Control Release. 2019 Oct 18;313:33-41. PubMed
The RNA-RNA base pairing potential of human Dicer and Ago2 proteins
Pokornowska M, Milewski MC, Ciechanowska K, Szczepańska A, Wojnicka M, Radogostowicz Z, Figlerowicz M, Kurzynska-Kokorniak A. Cell Mol Life Sci. 2019 Oct 26. PubMed
