How to Develop and Prove High-Efficiency Selection of Ligands from Oligonucleotide Libraries: A Universal Framework for Aptamers and DNA-Encoded Small-Molecule Ligands
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
Hovlinc is a recently evolved class of ribozyme found in human lncRNA
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
Super-resolution RNA imaging using a rhodamine-binding aptamer with fast exchange kinetics
Sunbul M, Lackner J, Martin A, Englert D, Hacene B, Grün F, Nienhaus K, Nienhaus GU, Jäschke A. Nat Biotechnol. 2021 Feb 11. Pubmed
A self-catabolic multifunctional DNAzyme nanosponge for programmable drug delivery and efficient gene silencing
Wang J, Yu S, Wu Q, Gong X, He S, Shang J, Liu X, Wang F. Angew Chem Int Ed Engl. 2021 Feb 18. Pubmed
Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes
Han D, Miao Y, Gao Q, Mao M, Zhang C, Yang L, Yang Y. Angew Chem Int Ed Engl. 2021 Feb 25 Pubmed
Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice
Sylvestre M, Lv S, Yang LF, Luera N, Peeler DJ, Chen BM, Roffler SR, Pun SH. J Control Release. 2021 Jan 11;331:142-153. Pubmed
A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
Zhao S, Tian R, Wu J, Liu S, Wang Y, Wen M, Shang Y, Liu Q, Li Y, Guo Y, Wang Z, Wang T, Zhao Y, Zhao H, Cao H, Su Y, Sun J, Jiang Q, Ding B. Nat Commun. 2021 Jan 13;12(1):358. Pubmed ...
Double Controlled Release of Therapeutic RNA Modules through Injectable DNA-RNA Hybrid Hydrogel
Han S, Park Y, Kim H, Nam H, Ko O, Lee JB. ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55554-55563. Pubmed
