Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
Hovlinc is a recently evolved class of ribozyme found in human lncRNA
Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.
siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M. Nucleic Acids Res. 2021 Feb 12 Pubmed
Perspectives on the Designation of Oligonucleotide Starting Materials
Kiesman WF, McPherson AK, Diorazio LJ, Van den Bergh L, Smith PD, Northall JM, Fettes A, Wang T, Mehlmann M, Raza S, Held G. Nucleic Acid Ther. 2021 Feb 2. Pubmed
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Vasquez G, Freestone GC, Wan WB, Low A, De Hoyos CL, Yu J, Prakash TP, Ǿstergaard ME, Liang XH, Crooke ST, Swayze EE, Migawa MT, Seth PP. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. Pubmed
Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice
Sylvestre M, Lv S, Yang LF, Luera N, Peeler DJ, Chen BM, Roffler SR, Pun SH. J Control Release. 2021 Jan 11;331:142-153. Pubmed
Double Controlled Release of Therapeutic RNA Modules through Injectable DNA-RNA Hybrid Hydrogel
Han S, Park Y, Kim H, Nam H, Ko O, Lee JB. ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55554-55563. Pubmed
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson’s disease
Yang J, Luo S, Zhang J, Yu T, Fu Z, Zheng Y, Xu X, Liu C, Fan M, Zhang Z. Neurobiol Dis. Epub 2020 Dec 6. Pubmed
Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
Biscans A, Caiazzi J, McHugh N, Hariharan V, Muhuri M, Khvorova A. Mol Ther. 2020 Dec 19:S1525-0016(20)30681-X. Pubmed
MOTS-c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton HM, Yin H. EMBO Mol Med. 2020 Dec 18:e12993. Pubmed
