The Oligonucleotide Therapeutics Society (OTS) is an open, nonprofit forum to foster research and development of oligonucleotide therapeutics.

The Founders’ vision was to bring together the expertise from different angles of oligonucleotide research to create synergies and to bring the field of oligonucleotides to its full therapeutic potential. A new era of oligonucleotide drugs was envisioned that would change the landscape of therapeutic modalities.

Oligonucleotide therapeutics are now being used to successfully treat diseases and have the potential for widespread application. Over 100 treatments are in development for common conditions, including cancer and Alzheimer’s disease, as well as rare diseases. Incredibly, oligonucleotide therapeutics have also been used to create an individualized treatment for one single person with a rare, fatal disease.

All the latest news


Martin Egli and Muthiah Manoharan’s Review of Approved Oligonucleotide Therapeutics


Amazon Prime for DNA – Has A New Era of Oligonucleotide Synthesis Begun?

Featured Member

Steven F. Dowdy, PhD

Steven F. Dowdy, Ph.D.

Department of Cellular & Molecular Medicine,
University of California San Diego (UCSD), School of Medicine

In 2004, we started addressing the siRNA (and ASO) delivery problem, which is really just the endosomal escape problem, that plagues all RNA therapeutics. We were the first lab to synthesize neutral, bioreversible phosphotriester groups on siRNAs…

Our work over the last 10 years has solely been focused on enhancing endosomal escape in a clinically acceptable non-toxic manner, which remains highly elusive.


Membership is an opportunity to take advantage of an array of benefits that support the society’s mission to foster academia and industry-based research and development of oligonucleotide therapeutics, all at a reasonable rate!


The Oligonucleotide Therapeutics Society offers the opportunity for both members and non-members to apply for various awards to support the accomplishments of students, postdocs and young investigators.



Upcoming Webinars

Introduction to Nucleic Acid Immunity, and It’s Implications For Optimizing Cancer Immunotherapy

5PM Amsterdam
Date: June  8, 2023
Speaker: Art Krieg, PhD

Past Webinars

Job Board

If you are looking for great people in the field of oligonucleotide therapeutics, we encourage you to post your job openings on our job board. It’s free to post!  Just register as an employer and start posting your openings.

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The OTS Job Board allows you to, Post/Edit Jobs Review/Filter Resumes Manage Employer Profiles


Search the latest job postings in the field of oligonucleotide therapeutics. The OTS Job Board allows you to: Search Jobs, Upload Resume, Create Job Alerts