Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs.
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Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH
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Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins
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Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats
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A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids
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