Antisense/RNase H

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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

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Hagedorn PH, Pontoppidan M, Bisgaard TS, Berrera M, Dieckmann A, Ebeling M, Møller MR, Hudlebusch H, Jensen ML, Hansen HF, Koch T, Lindow M.
Nucleic Acids Res. 2018 May 22.

PubMed

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May 31, 2018

Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr-/- mice

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Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr-/- mice

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Rajamoorthi A, Lee RG, Baldán Á.
Atherosclerosis. 2018 May 24;275:43-49.

PubMed

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May 31, 2018

Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs

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Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs

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Du X, Cai Q, West MB, Youm I, Huang X, Li W, Cheng W, Nakmali D, Ewert DL, Kopke RD.
Mol Ther. 2018 May 2;26(5):1313-1326.

PubMed

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May 31, 2018

Reversal of siRNA-mediated gene silencing in vivo

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Reversal of siRNA-mediated gene silencing in vivo

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Zlatev I, Castoreno A, Brown CR, Qin J, Waldron S, Schlegel MK, Degaonkar R, Shulga-Morskaya S, Xu H, Gupta S, Matsuda S, Akinc A, Rajeev KG, Manoharan M, Maier MA, Jadhav V.
Nat Biotechnol. 2018 May 14.

PubMed

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May 31, 2018