PEPCK1 antisense oligonucleotide prevents adiposity and impairs hepatic glycogen synthesis in high-fat male fed rats …………… Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov V, Church C, Rodeheffer M, Cline G, Geisler J, Bhanot S, Samuel VT. Endocrinology. 2018 Nov 15. PubMed
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis …………… Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB. Sci Transl Med. 2018 Nov 21;10(468). PubMed
Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression …………… Buntz A, Killian T, Schmid D, Seul H, Brinkmann U, Ravn J, Lindholm M, Knoetgen H, Haucke V, Mundigl O. Nucleic Acids Res. 2018 Nov 20. PubMed
RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade …………… Ganesh S, Shui X, Craig KP, Park J, Wang W, Brown BD, Abrams MT. Mol Ther. 2018 Nov 7;26(11):2567-2579 PubMed