Increased PIP3 activity blocks nanoparticle mRNA delivery.
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Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide.
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Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
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Aptamers with tunable affinity enable single-molecule tracking and localization of membrane receptors on living cancer cells.
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Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity.
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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
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A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing.
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Dual base editor catalyzes both cytosine and adenine base conversions in human cells.
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Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease.
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The biochemical basis for the cooperative action of microRNAs.
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