Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity
Liang XH, Nichols JG, De Hoyos CL, Crooke ST. Nucleic Acids Res. 2020 Sep 25;48(17):9840-9858 Pubmed
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy
Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, Tomassy GS, McCampbell A, Rigo F, Dickson DW, Shorter J, Zhang YJ, Petrucelli L. ...
August 2020 Joint Papers of the Month
Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression Lim KH, Han Z, Jeon HY, Kach J, Jing E, Weyn-Vanhentenryck S, Downs M, Corrionero A, Oh R, Scharner J, Venkatesh A, Ji S, Liau G, Ticho B, Nash H, Aznarez I. Nat Commun. ...
Interview with Aurélie Goyenvalle, PhD
Aurélie Goyenvalle, PhD University of Versailles Group Leader Biotherapy for Neuromuscular Diseases U1179 UVSQ-INSERM How did you become interested in the field of oligonucleotides? I started my PhD in 2002 in Genethon in France working on therapeutics for muscular dystrophies, and it was the ...
OTS 2020 List of Poster Winners
13 O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron William Copp, PhD Candidate, Concordia University 31 Vitamin Lipid Nanoparticles Enable Adoptive Macrophage Transfer for the Treatment of Multidrug-Resistant Bacterial Sepsis Xucheng Hou, Graduate Student, The Ohio State University 35 The Global Effects of TNRC6 ...
2021 OTS Lifetime Achievement Award Winner C. Frank Bennett, PhD
Frank Bennett, Ph.D. Ionis Pharmaceuticals Dr. Bennett is the executive vice president and chief scientific officer at Ionis Pharmaceuticals and one of the founding members of the company. He is responsible for continuing to advance antisense technology and expanding Ionis drug discovery platform. Dr. ...
2020 OTS Lifetime Achievement Award Winner Ryszard Kole, PhD
Ryszard Kole, PhD University of North Carolina, Chapel Hill Dr. Kole received his Ph.D. degree from the Institute of Biochemistry and Biophysics, Polish Academy of Sciences, in Warsaw, where he studied the role of ribonucleases on cell function. In 1977 he moved to USA ...
Antisense Drug Discovery and Development Technology Considered in a Pharmacological Context
Crooke ST, Liang XH, Crooke RM, Baker BF, Geary RS. Biochem Pharmacol. 2020 Aug 12:114196. Pubmed
Maximizing transcription of nucleic acids with efficient T7 promoters
Conrad T, Plumbom I, Alcobendas M, Vidal R, Sauer S. Commun Biol. 2020 Aug 14;3(1):439. Pubmed
Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment
Hewitt SL, Bailey D, Zielinski J, Apte A, Musenge F, Karp R, Burke S, Garcon F, Mishra A, Gurumurthy S, Watkins A, Arnold K, Moynihan J, Clancy-Thompson E, Mulgrew K, Adjei G, Deschler K, Potz D, Moody G, Leinster DA, Novick S, Sulikowski M, Bagnall ...
