13 O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron William Copp, PhD Candidate, Concordia University

31 Vitamin Lipid Nanoparticles Enable Adoptive Macrophage Transfer for the Treatment of Multidrug-Resistant Bacterial Sepsis Xucheng Hou, Graduate Student, The Ohio State University

35 The Global Effects of TNRC6 Knockout Samantha Johnson, Graduate Student, UT Southwestern

61 Reversible cardiac disease features in an inducible CUG-repeat RNA expressing mouse model of myotonic dystrophy Ashish Rao, Baylor College of Medicine

63 Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System Julia Rembetsy-Brown, RNA Therapeutics Institute, University of Massachusetts Medical School

69 Antisense Oligonucleotides Effectively Inhibit Nonsense-mediated Decay and Translation Termination Pathways to Upregulate Nonsense-mutated CFTR Expression and Function Edward Sanderlin, PhD, Ionis Pharmaceuticals

71 Method for Quantification of Antisense Oligonucleotides with an Enzymatic Ligation-Based Quantitative Polymerase Chain ReactionMinwook Shin, UMass Medical School

79 3-Amino-1,2-propanediol-linked Monomeric GalNAc Phosphoramidite for Efficient Delivery of Antisense Oligonucleotides to Hepatocytes Chisato Terada, Graduate School of Biomedical Sciences, Nagasaki University

81 Antisense oligonucleotide screening for the ABCA4 c.768G>T mutation underlying Stargardt disease Tomasz Tomkiewicz, MSc, Department of Human Genetics, Radboud University Medical Center

84 Effect of Chemically Modified siRNA on Strand Selection Andrew Varley, University of Ontario Institute of Technology

86 Non-repeat-targeted antisense oligonucleotides restore FXN expression in cell models of Friedreich’s Ataxia Feng Wang, RNA Therapeutics Institute, University of Massachusetts Medical School