Joint Papers of the Month: Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia. …………… Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. N Engl J Med. 2020 Mar 18. Prof. Frederick J. Raal Two Phase 3 Trials of…
Paper of the Month: A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis …………… Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. Nat Neurosci. 2020…
Joint Papers of the Month: Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination …………… Lai F, Damle SS, Ling KK, Rigo F. Mol Cell. 2020 Jan 3. pii: S1097-2765(19)30959-1. Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination. …………… Lee JS, Mendell JT. Mol Cell. 2020 Jan 2. pii:…
Paper of the Month: mRNA Structure Regulates Protein Expression Through Changes in Functional Half-Life …………… Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. Melissa J. Moore Iain J. McFadyen David…