Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, PĂ©rez Marc G, Moreira ED, Zerbini C, Bailey R, Swanson KA, Roychoudhury S, Koury K, Li P, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, TĂĽreci Ă–, Nell H, Schaefer A, Ăśnal S, Tresnan DB, Mather S, Dormitzer PR, Ĺžahin U, Jansen KU, Gruber WC; C4591001 Clinical Trial Group.
Building on previous work, here Asami, Nagata, Yoshioka and colleagues from the Tokyo Medical and Dental University and Ionis Pharmaceuticals investigate new heteroduplex oligonucleotide (HDO) designs for antisense oligonucleotides.
The chromosomal 2q21.3 locus has undergone positive selection in the last 5000 years in Europeans and this has long been attributed to the presence of the lactase gene.
Non-alcoholic steatohepatitis (NASH) is caused by accumulation of fat in the liver which can result in liver inflammation, cirrhosis and subsequent liver failure.