Kacherovsky N, Cardle II, Cheng EL, Yu JL, Baldwin ML, Salipante SJ, Jensen MC, Pun SH. Nat Biomed Eng. 2019 Jun 17. Genetically engineered chimeric antigen receptor (CAR) T-cell therapies for liquid cancers have shown excellent results in clinical trials and two were approved by the FDA for clinical use in 2017 (Kymriah and Yescarta).…
Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, Blair NF, Craufurd D, Priller J, Rickards H, Rosser A, Kordasiewicz HB, Czech C, Swayze EE, Norris DA, Baumann T, Gerlach I, Schobel SA, Paz E, Smith AV, Bennett CF, Lane RM. N Engl J Med. 2019 May 6 The success of nusinersen…
Gagnon KT, Corey DR. Nucleic Acid Ther. 2019 Mar 23. In addition to the widespread use of synthetic oligonucleotides to manipulate RNA levels in basic research, interest in oligonucleotide therapeutics has increased substantially due to the commercial success of recently approved nucleic acid drugs. In turn, this has led to an influx of scientists largely…
Janas MM, Zlatev I, Liu J, Jiang Y, Barros SA, Sutherland JE, Davis WP, Liu J, Brown CR, Liu X, Schlegel MK, Blair L, Zhang X, Das B, Tran C, Aluri K, Li J, Agarwal S, Indrakanti R, Charisse K, Nair J, Matsuda S, Rajeev KG, Zimmermann T, Sepp-Lorenzino L, Xu Y, Akinc A, Fitzgerald…