Joint Papers of the Month: Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults. Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil K, Raabe V, Bailey R, Swanson KA, Li P, Koury K, Kalina W, Cooper D, Fontes-Garfias C, Shi PY, Türeci Ö, Tompkins KR, Walsh EE, Frenck R,…
Paper of the Month Reversing a Model of Parkinson’s Disease With in Situ Converted Nigral Neurons Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. Nature. 2020 Jun;582(7813):550-556. Dr. Hao Qian Parkinson’s Disease…
Paper of the Month: Base-pair Conformational Switch Modulates miR-34a Targeting of Sirt1 mRNA …………… Baronti L, Guzzetti I, Ebrahimi P, Friebe Sandoz S, Steiner E, Schlagnitweit J, Fromm B, Silva L, Fontana C, Chen AA, Petzold K. Nature. 2020 May 27 The first author: Lorenzo Baronti As part of RNA-induced silencing complexes (RISCs), microRNAs bind…
Paper of the Month: Imaging small molecule-induced endosomal escape of siRNA …………… Du Rietz H, Hedlund H, Wilhelmson S, Nordenfelt P, Wittrup A. Nat Commun. 2020 Apr 14;11(1):1809. Hampus Du Rietz and Dr. Anders Wittrup Delivery is currently the biggest hurdle oligonucleotide therapeutics face to become effective treatments. Oligonucleotide therapeutics not only need to…