October 2017 Paper of the Month

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

Bailey JK, Shen W, Liang XH, Crooke ST. Nucleic Acids Res. 2017 Oct 13;45(18):10649-10671. This paper is the latest in a series of publications from Stanley Crooke’s lab at Ionis investigating the interactions between phosphorothioate antisense oligonucleotides and intracellular proteins. The lab has previously identified over 50 intracellular proteins that bind PS-ASOs and shown that…