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29September, 2019

Quantification Methods for oligonucleotide therapeutics in serum and tissue

September 29th, 2019|Categories: Past Webinars|

Presenter: Mai Thayer, Amgen, USA Date: October 8, 2019 Description: Oligonucleotides are a quickly evolving modality with strong proof of concept established in the clinic. Despite the clinical success of oligonucleotides, there is still limited understanding of ADME (absorption, disposition, metabolism and excretion) in comparison to other modalities (e.g. ...

16May, 2019

Advances in SELEX technologies for aptamer selection

May 16th, 2019|Categories: Past Webinars|

Presenter: Günter Mayer, University of Bonn, Germany Date: August 27, 2019 Description: Aptamers are short single-stranded oligonucleotides, selected to interact with target molecules with high affinity and specificity. These characteristics and their versatile applicability, make aptamers universal molecular probes in biotechnological and therapeutic applications. However, the chemical repertoire of ...

11April, 2019

Design of microRNA therapeutics

April 11th, 2019|Categories: Past Webinars|

Presenter: Andrea Kasinski, Purdue University, USA Date: May 15, 2019 Description: MicroRNAs (miRNAs) have emerged as powerful regulators of the genome and, through concerted efforts to identify their function and evaluate their ability to alter cell growth in vitro and in vivo, some have gained favor as potential therapeutics. ...

11April, 2019

Targeted delivery using aptamers

April 11th, 2019|Categories: Past Webinars|

Presenter: Donald H. Burke/David Porciani, University of Missouri, USA Date: July 25, 2019 Description: Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs (<15 kDa, 19-21 nt/strand) to large, functional ...

13February, 2019

An Overview of Chemical Modifications to CRISPR RNA

February 13th, 2019|Categories: Past Webinars|

Presenter: Keith Gagnon, Southern Illinois University, USA Date: March 21, 2019 Description: CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of CRISPR enzymes and the spectrum ...

15November, 2018

Pitfalls and problems of miRNA expression analysis

November 15th, 2018|Categories: Past Webinars|

Presenter: Michela Denti PhD, University of Trento, Italy Prof. Denti has an unavoidable commitment that came up on short notice and has arranged for Simone Detassis from her lab to give the webinar in her place. Date: February 12, 2019 Description: microRNAs are intensively studied as tools for personalized ...

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