How to test for immune activation by your therapeutic oligonucleotide

June 18th, 2021|Categories: Past Webinars|

Presenter: Arthur M. Krieg, MD, Checkmate Pharmaceuticals Date: 19 April 2018 Description: RNA and DNA oligonucleotides with charged backbones commonly cause immune activation, which can be recognized by appropriate in vitro and/or in vivo testing. Eukaryotic innate immune systems have evolved multiple receptors to [...]

Designing siRNAs for improving their therapeutic applications

January 27th, 2021|Categories: Past Webinars|

Presenter: Dr. Annabelle Biscans (AstraZeneca)  Date: January 27th, 2021 Description: Small interfering RNAs (siRNAs) have the potential to revolutionize medicine due to their potency, duration of effect, and ability to target previously “undruggable” disease genes. The clinical success of siRNAs is dependent on their [...]

The N-Lorem Foundation

November 18th, 2020|Categories: Past Webinars|

Presenter: Stanley T. Crooke, MD, PhD Ionis Pharmaceuticals Date: February 9th, 2021 Description: The purpose of this presentation is to formally introduce n-Lorem to OTS and to summarize progress since being founded in January 2020. Recording of the webinar: Click play to view [...]

Academia or Industry? A career discussion

June 19th, 2020|Categories: Past Webinars|

Presenter: Prof. Annemieke Aartsma-Rus, (OTS President; Leiden University Medical Center) and Dr. Shalini Andersson (Chief Scientist New Therapeutic Modalities and Head of Oligonucleotide Discovery, AstraZeneca) Date: July 15, 2020 Description: To start off, Prof. Annemieke Aartsma-Rus (OTS President; Leiden University Medical Center) and Dr. [...]

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