Spotting Stubborn Indirect Effects in Oligonucleotide Therapeutics

January 10th, 2023|Categories: Past Webinars|

Time: 4pm CET Date: March 16, 2023 We use chemistry to improve the properties of nucleic acid therapeutics including antisense oligonucleotides, siRNAs, and genome editing approaches. I will walk through a recent study we carried out trying to activate frataxin expression to treat ...

Towards Developing Greener Methods for Oligonucleotide Synthesis

December 26th, 2022|Categories: Past Webinars|

Time: 5pm Amsterdam - 9 AM MST Date: February 23, 2023 Research: My research focuses on the development of novel methodologies for oligonucleotide synthesis, with a particular emphasis on reducing the solvent footprint of oligonucleotide synthesis. Webinar topic: My webinar will largely focus on ...

An insider’s view into the preclinical development of an approved exon skipping drug

October 21st, 2022|Categories: Past Webinars|

Time: 11am - 12pm EST Date: November 3, 2022 Description: Dr. Arechavala works on developing new drugs for neuromuscular disorders. As there are not many for these rare diseases, neuromuscular disorders have been at the forefront of the clinical development of RNA based ...

Site-specific detection of mutagenic DNA damage with an artificial nucleotide

October 21st, 2022|Categories: Past Webinars|

Time: 11am - 12pm EST Date: October 27, 2022 Description: Incorporating nucleotides with altered structures that are derived synthetically is a strategy that has been used widely to interrogate biological processes involving DNA. Particularly, synthetic nucleotides able to stabilize damaged over undamaged templates ...

Patient Advocacy and Therapeutic Development for Huntington’s Disease

July 29th, 2022|Categories: Past Webinars|

Time: 11am - 12pm EST Date: August 11, 2022 Description: Dan O'Reilly, PhD, a former OTS Trainee BoD member, focuses his research on developing siRNA therapeutics for Huntington’s Disease. Join us as Dr. O'Reilly discusses patient advocacy and Huntington’s Disease research. ...

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