Guidelines for Experiments using Antisense Oligonucleotides and Double-Stranded RNAs

November 15th, 2018|Categories: Past Webinars|

Presenter: David Corey PhD, University of Texas, USA Date: 6 December 2018 Description: After decades of research and development, synthetic nucleic acids are beginning to enjoy significant success in the clinic. Approved drugs have increased interest in the field and many basic research studies ...

Oligonucleotide Therapeutics: Technology Evolution for Clinically Relevant Tissue Delivery

June 22nd, 2018|Categories: Past Webinars|

Presenter: Anastasia Khvorova, PhD, RNA Therapeutics Institute, University of Massachusetts Medical School Date: 10 September 2018 Description: A decade of progress in oligonucleotide chemistry and formulation development has resulted in several compounds, both siRNAs and antisense, demonstrating robust clinical activity. Based on sequence, these ...

Design of Exon Skipping Oligonucleotides

January 25th, 2018|Categories: Past Webinars|

Presenter: Annemieke Aartsma-Rus, PhD, Leiden University Medical Center Date: 20 February 2018 Description: Antisense-mediated splicing modulation utilizes antisense oligonucleotides (ASOs) to manipulate the splicing by sterically blocking the binding of splicing factors to pre-mRNA transcripts. While in industry often oligo walks are used to ...

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