Past Webinars

Presenter: Patrik Andersson (AstraZeneca) Date: May 13, 2020 Description: Successful therapeutics need to be efficacious and safe. Although oligonucleotide therapeutics act via unique mechanisms, they follow the same principles for safety assessment as other modalities. This webinar will give an overview of these principles and what ...

Presenter: Steven Dowdy (UCSD School of Medicine) Date: December 17, 2019 Description: All macromolecular therapeutics, including ASOs, siRNAs, peptides, proteins, CRISPR, mRNA and non-viral DNA vectors, are taken up into cells by endocytosis. However, <1% to none of the endocytosed therapeutic cargo escapes into the cytoplasm ...

Presenter: Grace Chen (Yale School of Medicine) Date: March 25, 2020 Description: Circular RNAs are a newly appreciated class of ubiquitous and abundant RNAs. In the webinar, we will cover biological and chemical approaches to synthesize circular RNAs, how cells distinguish between endogenous and foreign circular RNAs, ...

Presenter: Robert MacLeod (Ionis Pharmaceuticals) Date: February 26, 2020 Recording of the webinar: Click play to view Presenter Biography Robert MacLeod (Ionis Pharmaceuticals) Dr. MacLeod is currently the Vice President Oncology ...

Presenter: Daniel O’Reilly and Joseph Ochaba (Oligonucleotide Therapeutics Society) Date: November 19, 2019 Description: With a constantly growing list of oligonucleotide therapies that are entering the clinics, these exciting research molecules-turned-therapeutic strategy are starting to lead the way in treatments for many devastating diseases. ...

Presenter: Mai Thayer, Amgen, USA Date: October 8, 2019 Description: Oligonucleotides are a quickly evolving modality with strong proof of concept established in the clinic. Despite the clinical success of oligonucleotides, there is still limited understanding of ADME (absorption, disposition, metabolism and excretion) in ...

Presenter: Günter Mayer, University of Bonn, Germany Date: August 27, 2019 Description: Aptamers are short single-stranded oligonucleotides, selected to interact with target molecules with high affinity and specificity. These characteristics and their versatile applicability, make aptamers universal molecular probes in biotechnological and therapeutic applications. ...

Presenter: Andrea Kasinski, Purdue University, USA Date: May 15, 2019 Description: MicroRNAs (miRNAs) have emerged as powerful regulators of the genome and, through concerted efforts to identify their function and evaluate their ability to alter cell growth in vitro and in vivo, some have ...

Presenter: Donald H. Burke/David Porciani, University of Missouri, USA Date: July 25, 2019 Description: Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs ...

Presenter: Keith Gagnon, Southern Illinois University, USA Date: March 21, 2019 Description: CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of ...