Past Webinars

11April, 2019

Design of microRNA therapeutics

April 11th, 2019|Categories: Past Webinars|

Presenter: Andrea Kasinski, Purdue University, USA Date: May 15, 2019 Description: MicroRNAs (miRNAs) have emerged as powerful regulators of the genome and, through concerted efforts to identify their function and evaluate their ability to alter cell growth in vitro and in vivo, some have gained favor as potential therapeutics. [...]

11April, 2019

Targeted delivery using aptamers

April 11th, 2019|Categories: Past Webinars|

Presenter: Donald H. Burke/David Porciani, University of Missouri, USA Date: July 25, 2019 Description: Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs (<15 kDa, 19-21 nt/strand) to large, functional [...]

13February, 2019

An Overview of Chemical Modifications to CRISPR RNA

February 13th, 2019|Categories: Past Webinars|

Presenter: Keith Gagnon, Southern Illinois University, USA Date: March 21, 2019 Description: CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of CRISPR enzymes and the spectrum [...]

15November, 2018

Pitfalls and problems of miRNA expression analysis

November 15th, 2018|Categories: Past Webinars|

Presenter: Michela Denti PhD, University of Trento, Italy Prof. Denti has an unavoidable commitment that came up on short notice and has arranged for Simone Detassis from her lab to give the webinar in her place. Date: February 12, 2019 Description: microRNAs are intensively studied as tools for personalized [...]

15November, 2018

Guidelines for Experiments using Antisense Oligonucleotides and Double-Stranded RNAs

November 15th, 2018|Categories: Past Webinars|

Presenter: David Corey PhD, University of Texas, USA Date: 6 December 2018 Description: After decades of research and development, synthetic nucleic acids are beginning to enjoy significant success in the clinic. Approved drugs have increased interest in the field and many basic research studies have focused on synthetic nucleic [...]

22June, 2018

Oligonucleotide Therapeutics: Technology Evolution for Clinically Relevant Tissue Delivery

June 22nd, 2018|Categories: Past Webinars|

Presenter: Anastasia Khvorova, PhD, RNA Therapeutics Institute, University of Massachusetts Medical School Date: 10 September 2018 Description: A decade of progress in oligonucleotide chemistry and formulation development has resulted in several compounds, both siRNAs and antisense, demonstrating robust clinical activity. Based on sequence, these types of drugs can be [...]

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