Past Webinars

11December, 2019

Delivery of Macromolecular Therapeutics: Tackling a Billion Year Old Barrier

December 11th, 2019|Categories: Past Webinars|

Presenter: Steven Dowdy (UCSD School of Medicine) Date: December 17, 2019 Description: All macromolecular therapeutics, including ASOs, siRNAs, peptides, proteins, CRISPR, mRNA and non-viral DNA vectors, are taken up into cells by endocytosis. However, <1% to none of the endocytosed therapeutic cargo escapes into the cytoplasm and nucleus of the cell. [...]

20November, 2019

Circular RNA Immunity

November 20th, 2019|Categories: Past Webinars|

Presenter: Grace Chen (Yale School of Medicine) Date: March 25, 2020 Description: Circular RNAs are a newly appreciated class of ubiquitous and abundant RNAs. In the webinar, we will cover biological and chemical approaches to synthesize circular RNAs, how cells distinguish between endogenous and foreign circular RNAs, and properties of circular RNAs [...]

19November, 2019

Antisense Oligonucleotides- Mechanisms of Action and Rational Design

November 19th, 2019|Categories: Past Webinars|

Presenter: Robert MacLeod (Ionis Pharmaceuticals) Date: February 26, 2020 Recording of the webinar: Click play to view Presenter Biography Robert MacLeod (Ionis Pharmaceuticals) Dr. MacLeod is currently the Vice President Oncology Research and Development, and Franchise [...]

30September, 2019

Patient Representative Webinar

September 30th, 2019|Categories: Past Webinars|

Presenter: Daniel O’Reilly and Joseph Ochaba (Oligonucleotide Therapeutics Society) Date: November 19, 2019 Description: With a constantly growing list of oligonucleotide therapies that are entering the clinics, these exciting research molecules-turned-therapeutic strategy are starting to lead the way in treatments for many devastating diseases. At their core, an Oligonucleotide [...]

29September, 2019

Quantification Methods for oligonucleotide therapeutics in serum and tissue

September 29th, 2019|Categories: Past Webinars|

Presenter: Mai Thayer, Amgen, USA Date: October 8, 2019 Description: Oligonucleotides are a quickly evolving modality with strong proof of concept established in the clinic. Despite the clinical success of oligonucleotides, there is still limited understanding of ADME (absorption, disposition, metabolism and excretion) in comparison to other modalities (e.g. [...]

16May, 2019

Advances in SELEX technologies for aptamer selection

May 16th, 2019|Categories: Past Webinars|

Presenter: Günter Mayer, University of Bonn, Germany Date: August 27, 2019 Description: Aptamers are short single-stranded oligonucleotides, selected to interact with target molecules with high affinity and specificity. These characteristics and their versatile applicability, make aptamers universal molecular probes in biotechnological and therapeutic applications. However, the chemical repertoire of [...]

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