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27January, 2021

Making medicines out of pre-mRNA splicing modulators

January 27th, 2021|Categories: Past Webinars|

Presenter: Isabel Aznarez, Ph.D. Stoke Therapeutics Date: April 29th, 2021 Description: Splicing is the process that edits precursor-messenger RNA (pre-mRNA) to generate the messenger RNA (mRNA) that carries the code from the nucleus to the cytoplasm where the ribosomes will translate it into a protein. The splicing reaction is [...]

18November, 2020

The N-Lorem Foundation

November 18th, 2020|Categories: Past Webinars|

Presenter: Stanley T. Crooke, MD, PhD Ionis Pharmaceuticals Date: February 9th, 2021 Description: The purpose of this presentation is to formally introduce n-Lorem to OTS and to summarize progress since being founded in January 2020. Recording of the webinar: Click play to view [...]

19June, 2020

Academia or Industry? A career discussion

June 19th, 2020|Categories: Past Webinars|

Presenter: Prof. Annemieke Aartsma-Rus, (OTS President; Leiden University Medical Center) and Dr. Shalini Andersson (Chief Scientist New Therapeutic Modalities and Head of Oligonucleotide Discovery, AstraZeneca) Date: July 15, 2020 Description: To start off, Prof. Annemieke Aartsma-Rus (OTS President; Leiden University Medical Center) and Dr. Shalini Andersson (Chief Scientist New [...]

5June, 2020

Time matters! – Why PK/PD is important for oligo development

June 5th, 2020|Categories: Past Webinars|

Presenter: Carl Amilon (AstraZeneca) Date: June 10, 2020 Description: This webinar will give an overview of how incorporating quantitative PK/PD aspects of an oligonucleotide will help you designing more informative experiments and help in translating to a human. We have all struggled with questions around the expectations of a study outcome [...]

1April, 2020

Safety of Therapeutic Oligonucleotides

April 1st, 2020|Categories: Past Webinars|

Presenter: Patrik Andersson (AstraZeneca) Date: May 13, 2020 Description: Successful therapeutics need to be efficacious and safe. Although oligonucleotide therapeutics act via unique mechanisms, they follow the same principles for safety assessment as other modalities. This webinar will give an overview of these principles and what needs to be considered from [...]

11December, 2019

Delivery of Macromolecular Therapeutics: Tackling a Billion Year Old Barrier

December 11th, 2019|Categories: Past Webinars|

Presenter: Steven Dowdy (UCSD School of Medicine) Date: December 17, 2019 Description: All macromolecular therapeutics, including ASOs, siRNAs, peptides, proteins, CRISPR, mRNA and non-viral DNA vectors, are taken up into cells by endocytosis. However, <1% to none of the endocytosed therapeutic cargo escapes into the cytoplasm and nucleus of the cell. [...]

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