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13February, 2019

An Overview of Chemical Modifications to CRISPR RNA

Categories: Past Webinars|

Presenter: Keith Gagnon, Southern Illinois University, USA Date: March 21, 2019 Description: CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of CRISPR enzymes and the spectrum ...

15November, 2018

Guidelines for Experiments using Antisense Oligonucleotides and Double-Stranded RNAs

Categories: Past Webinars|

Presenter: David Corey PhD, University of Texas, USA Date: 6 December 2018 Description: After decades of research and development, synthetic nucleic acids are beginning to enjoy significant success in the clinic. Approved drugs have increased interest in the field and many basic research studies have focused on synthetic nucleic ...

22June, 2018

Oligonucleotide Therapeutics: Technology Evolution for Clinically Relevant Tissue Delivery

Categories: Past Webinars|

Presenter: Anastasia Khvorova, PhD, RNA Therapeutics Institute, University of Massachusetts Medical School Date: 10 September 2018 Description: A decade of progress in oligonucleotide chemistry and formulation development has resulted in several compounds, both siRNAs and antisense, demonstrating robust clinical activity. Based on sequence, these types of drugs can be ...

30April, 2018

Basics of intellectual property and patenting

Categories: Past Webinars|

Presenter: Laurence Gainey, PhD, HGF Intellectual Property Specialists Date: May 24th 2018 Description: This webinar will be a short, basic introduction to the process of patenting as it applies to biotherapeutics, including some territorial differences. It will cover the core requirements for a patent and the processes for obtaining ...

25January, 2018

Design of Exon Skipping Oligonucleotides

Categories: Past Webinars|

Presenter: Annemieke Aartsma-Rus, PhD, Leiden University Medical Center Date: 20 February 2018 Description: Antisense-mediated splicing modulation utilizes antisense oligonucleotides (ASOs) to manipulate the splicing by sterically blocking the binding of splicing factors to pre-mRNA transcripts. While in industry often oligo walks are used to identify the most optimal ASO, ...

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