Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins
Zhang L, Vickers TA, Sun H, Liang XH, Crooke ST. Nucleic Acids Res. 2021 Feb 12:gkab078. Pubmed
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models
Liu Y, Dodart JC, Tran H, Berkovitch S, Braun M, Byrne M, Durbin AF, Hu XS, Iwamoto N, Jang HG, Kandasamy P, Liu F, Longo K, Ruschel J, Shelke J, Yang H, Yin Y, Donner A, Zhong Z, Vargeese C, Brown RH Jr. Nat Commun. ...
Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats
Derbis M, Kul E, Niewiadomska D, Sekrecki M, Piasecka A, Taylor K, Hukema RK, Stork O, Sobczak K. Nat Commun. 2021 Feb 24;12(1):1265. Pubmed
November 2020 Paper of the Month
Building on previous work, here Asami, Nagata, Yoshioka and colleagues from the Tokyo Medical and Dental University and Ionis Pharmaceuticals investigate new heteroduplex oligonucleotide (HDO) designs for antisense oligonucleotides.
The Emerging Era of N-of-1 Drugs for Ultra-Rare Genetic Diseases
Imagine if a medication or therapy could be created to treat just one individual with an ultra-rare disease. There are nearly 7,000 known rare diseases (1) and many are debilitating and ultimately fatal. In the U.S., a disease is considered rare when it affects ...
A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids
Fantoni NZ, El-Sagheer AH, Brown T. Chem Rev. 2021 Jan 14. Pubmed
MiR-CLIP reveals iso-miR selective regulation in the miR-124 targetome
Wang Y, Soneson C, Malinowska AL, Laski A, Ghosh S, Kanitz A, Gebert LFR, Robinson MD, Hall J. Nucleic Acids Res. 2021 Jan 11;49(1):25-37 Pubmed
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming
Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT. Science. 2020 Dec 18;370(6523):eabc9546. Pubmed
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation
Shi CY, Kingston ER, Kleaveland B, Lin DH, Stubna MW, Bartel DP. Science. 2020 Dec 18;370(6523):eabc9359. Pubmed
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition
Agirre E, Oldfield AJ, Bellora N, Segelle A, Luco RF. Nat Commun. 2021 Jan 29;12(1):682. Pubmed
