Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

AUTHOR

OTS

DATE

March 15, 2021

CATEGORIES

Antisense/RNase H

Post Views: 335

Zhang L, Vickers TA, Sun H, Liang XH, Crooke ST.

Nucleic Acids Res. 2021 Feb 12:gkab078.

Pubmed

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Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

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Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

Related articles

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease

Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome

Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

Safety, Pharmacokinetic and Pharmacodynamic Evaluation of a 2′-MOE Antisense Oligonucleotide-GalNAc3 Conjugate that Targets the Human Transmembrane Protease Serine 6 (TMPRSS6)

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