Oligonucleotide Therapeutics Society

IKARIA – An Innovative Platform that Yields Long-Acting siRNA

November 10th, 2021|Categories: Perspectives on Current Science|

In this year that marks the 20th Anniversary of the discovery of RNA interference as a gene-silencing mechanism in mammalian cells, Alnylam announced another remarkable development in siRNA therapeutics – a platform that could allow for administration of siRNA medications just once a year [...]

Oligonucleotide Therapies and COVID-19

October 31st, 2021|Categories: Archive|

In response to the COVID-19 pandemic, scientists around the world have joined together in applying their skills and technologies to fight this global threat. Some of the most promising technologies to fight the coronavirus are based on oligonucleotide therapeutics.  In an effort to promote public [...]

2021 Basic Paper Of The Year Award – Winners

October 28th, 2021|Categories: Paper of the Year Award, Basic Featured Paper of the Year|

Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or [...]

2021 Mary Ann Liebert Publishers, Inc. Young Investigator Award

October 28th, 2021|Categories: Young Investigator Award|

Alex Garanto, PhD Radboud University Medical Center (Radboudumc) Biography: Dr. Alejandro (Alex) Garanto is currently an Assistant Professor at the Departments of Pediatrics and Human Genetics of the Radboudumc in Nijmegen (the Netherlands). He obtained his PhD from the University of Barcelona in 2011 [...]

2021 Dr. Alan M. Gewirtz Memorial Scholarship Award for Postdoctoral Fellows and Junior Industrial Professionals

October 28th, 2021|Categories: Dr. Alan M. Gewirtz Memorial Scholarship|

Kotaro Yoshioka, MD, PhD Department of Neurology and Neurological Science, Tokyo Medical and Dental University Biography: Kotaro Yoshioka received his PhD in 2016 from Tokyo Medical and Dental University (Japan), where he has developed a unique double-stranded ASO technology, “Heteroduplex oligonucleotide (HDO)” in the laboratory [...]

2021 Dr. Alan M. Gewirtz Memorial Scholarship Award for Graduate Students Winner Mr. Hassan Fakih

October 28th, 2021|Categories: Dr. Alan M. Gewirtz Memorial Scholarship|

Mr. Hassan Fakih Department of Chemistry, McGill University Biography: Hassan obtained his bachelor’s degree in chemistry from the American University of Beirut in 2016. Then, he Joined the Sleiman Lab at the Chemistry department of McGill University to pursue his doctorate degree. His work [...]

New Miniature CRISPR-Cas Systems Engineered to Function in Human Cells

October 28th, 2021|Categories: Perspectives on Current Science|

CRISPR-Cas systems provide a revolutionary approach to curing disease through precise genome editing and CRISPR therapies have delivered promising early successes. However, engineering more highly efficient, compact Cas systems could result in a more versatile tool that could greatly improve and expand CRISPR-based therapeutics. [...]

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