Highly parallel direct RNA sequencing on an array of nanopores
Garalde DR, Snell EA, Jachimowicz D, Sipos B, Lloyd JH, Bruce M, Pantic N, Admassu T, James P, Warland A, Jordan M, Ciccone J, Serra S, Keenan J, Martin S, McNeill L, Wallace EJ, Jayasinghe L, Wright C, Blasco J, Young S, Brocklebank D, Juul ...
High-throughput identification of RNA nuclear enrichment sequences
Shukla CJ, McCorkindale AL, Gerhardinger C, Korthauer KD, Cabili MN, Shechner DM, Irizarry RA, Maass PG, Rinn JL. EMBO J. 2018 Jan 15. pii: e98452. PubMed
The Expanding Landscape of Alternative Splicing Variation in Human Populations
Park E, Pan Z, Zhang Z, Lin L, Xing Y. Am J Hum Genet. 2018 Jan 4;102(1):11-26. PubMed
DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides
Hu Q, Wang S, Wang L, Gu H, Fan C. Adv Healthc Mater. 2018 Jan 22. PubMed
Functional Classification and Experimental Dissection of Long Noncoding RNAs
Kopp F, Mendell JT. Cell. 2018 Jan 25;172(3):393-407. PubMed
The Role of micro RNAs in Breast Cancer Metastasis: Preclinical Validation and Potential Therapeutic Targets
Weidle UH, Dickopf S, Hintermair C, Kollmorgen G, Birzele F, Brinkmann U. Cancer Genomics Proteomics. 2018 Jan-Feb;15(1):17-39. PubMed
Life under the Microscope: Single-Molecule Fluorescence Highlights the RNA World
Ray S, Widom JR, Walter NG. Chem Rev. 2018 Jan 24. PubMed
Design of Exon Skipping Oligonucleotides
Presenter: Annemieke Aartsma-Rus, PhD, Leiden University Medical Center Date: 20 February 2018 Description: Antisense-mediated splicing modulation utilizes antisense oligonucleotides (ASOs) to manipulate the splicing by sterically blocking the binding of splicing factors to pre-mRNA transcripts. While in industry often oligo walks are used to ...
Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides
Bailey JK, Shen W, Liang XH, Crooke ST. Nucleic Acids Res. 2017 Oct 13;45(18):10649-10671. Dr. Jeffrey Bailey This paper is the latest in a series of publications from Stanley Crooke’s lab at Ionis investigating the interactions between phosphorothioate antisense oligonucleotides and intracellular proteins. ...
Interview with Vadim Y Dudkin, PhD
I first became exposed to oligonucleotide delivery while at Merck upon the acquisition of Sirna in 2006. Part of my work at the time involved glyco
