Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Anderson EJ, Rouphael NG, Widge AT, Jackson LA, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Corbett KS, Swanson PA 2nd, Padilla M, Neuzil KM, Bennett H, Leav B, ...
Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data
Viney NJ, Guo S, Tai LJ, Baker BF, Aghajan M, Jung SW, Yu RZ, Booten S, Murray H, Machemer T, Burel S, Murray S, Buchele G, Tsimikas S, Schneider E, Geary RS, Benson MD, Monia BP. ESC Heart Fail. 2020 Dec 7. Pubmed ...
Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
Esrick EB, Lehmann LE, Biffi A, Achebe M, Brendel C, Ciuculescu MF, Daley H, MacKinnon B, Morris E, Federico A, Abriss D, Boardman K, Khelladi R, Shaw K, Negre H, Negre O, Nikiforow S, Ritz J, Pai SY, London WB, Dansereau C, Heeney MM, ...
Double Controlled Release of Therapeutic RNA Modules through Injectable DNA-RNA Hybrid Hydrogel
Han S, Park Y, Kim H, Nam H, Ko O, Lee JB. ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55554-55563. Pubmed
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson’s disease
Yang J, Luo S, Zhang J, Yu T, Fu Z, Zheng Y, Xu X, Liu C, Fan M, Zhang Z. Neurobiol Dis. Epub 2020 Dec 6. Pubmed
Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
Biscans A, Caiazzi J, McHugh N, Hariharan V, Muhuri M, Khvorova A. Mol Ther. 2020 Dec 19:S1525-0016(20)30681-X. Pubmed
MOTS-c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton HM, Yin H. EMBO Mol Med. 2020 Dec 18:e12993. Pubmed
DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences
Hoshino H, Kasahara Y, Kuwahara M, Obika S. J Am Chem Soc. 2020 Dec 23;142(51):21530-21537. Pubmed
Enzymatic synthesis of hypermodified DNA polymers for sequence-specific display of four different hydrophobic groups
OndruÅ¡ M, SĂ½korovĂ¡ V, BednĂ¡rovĂ¡ L, Pohl R, Hocek M. Nucleic Acids Res. 2020 Dec 2;48(21):11982-11993. Pubmed
Accelerating Post-SELEX Aptamer Engineering Using Exonuclease Digestion
Canoura J, Yu H, Alkhamis O, Roncancio D, Farhana R, Xiao Y. J Am Chem Soc. 2021 Jan 20;143(2):805-816. Pubmed
