Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p.
Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender I, Haller H, Kistler AD, Dueck A, Engelhardt S, Thum T, Mueller TF, Wüthrich RP, Lorenzen JM. J Am Soc Nephrol. 2021 Feb;32(2):323-341. Pubmed
Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH. Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. Pubmed
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption
Mondala PK, Vora AA, Zhou T, Lazzari E, Ladel L, Luo X, Kim Y, Costello C, MacLeod AR, Jamieson CHM, Crews LA. Cell Stem Cell. 2021 Jan 20:S1934-5909(20)30601-9. Pubmed
Facts about COVID-19 mRNA Vaccines and the Decades of Research That Went into Creating Them
Posted: February 11, 2021 | Updated: October 8, 2021 Despite the global threat of COVID-19, mRNA vaccines, which are highly effective at preventing COVID-19 illness and have passed rigorous safety standards, have been met with skepticism by many people. This suspicion is due in ...
Interview with Julia Alterman
Julia Alterman, PhD RNA Therapeutics Institute, University of Massachusetts Medical School How did you become interested in the field of oligonucleotides? After finishing my bachelor’s degree at the University of Vermont I started my scientific career in the vibrant Boston biotech community. My first ...
Clinical Pharmacology Studies Supporting Oligonucleotide Therapy Development: An Assessment of Therapies Approved and in Development Between 2012-2018
Rogers H, Adeniyi O, Ramamoorthy A, Bailey S, Pacanowski M. Clin Transl Sci. 2020 Dec 5. Pubmed
RNA structure-wide discovery of functional interactions with multiplexed RNA motif library
Komatsu KR, Taya T, Matsumoto S, Miyashita E, Kashida S, Saito H. Nat Commun. 2020 Dec 8;11(1):6275. Pubmed
Functional Atlas of Primary miRNA Maturation by the Microprocessor
Rice GM, Shivashankar V, Ma EJ, Baryza JL, Nutiu R. Mol Cell. 2020 Dec 3;80(5):892-902.e4. Pubmed
Screening for functional circular RNAs using the CRISPR-Cas13 system
Li S, Li X, Xue W, Zhang L, Yang LZ, Cao SM, Lei YN, Liu CX, Guo SK, Shan L, Wu M, Tao X, Zhang JL, Gao X, Zhang J, Wei J, Li J, Yang L, Chen LL. Nat Methods. Epub 2020 Dec 7. Pubmed ...
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C, Bailey R, Swanson KA, Roychoudhury S, Koury K, Li P, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer ...
