TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target
Kennedy E, Coulter EM, Halliwell E, Profitos-Peleja N, Walsby E, Clark B, Phillips EH, Burley TA, Mitchell S, Devereux S, Fegan C, Jones CI, Johnston R, Chevassut TJ, Schulz R, Seiffert M, Agathanggelou A, Oldreive C, Davies NJ, Stankovic T, Liloglou T, Pepper C, Pepper ...
Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice
Sylvestre M, Lv S, Yang LF, Luera N, Peeler DJ, Chen BM, Roffler SR, Pun SH. J Control Release. 2021 Jan 11;331:142-153. Pubmed
A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
Zhao S, Tian R, Wu J, Liu S, Wang Y, Wen M, Shang Y, Liu Q, Li Y, Guo Y, Wang Z, Wang T, Zhao Y, Zhao H, Cao H, Su Y, Sun J, Jiang Q, Ding B. Nat Commun. 2021 Jan 13;12(1):358. Pubmed ...
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice
Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR. Nature. 2021 Jan;589(7843):608-614. ...
iR-10b-5p Rescues Diabetes and Gastrointestinal Dysmotility
Singh R, Ha SE, Wei L, Jin B, Zogg H, Poudrier SM, Jorgensen BG, Park C, Ronkon CF, Bartlett A, Cho S, Morales A, Chung YH, Lee MY, Park JK, Gottfried-Blackmore A, Nguyen L, Sanders KM, Ro S. Gastroenterology. 2021 Jan 7:S0016-5085(21)00001-9. Pubmed ...
Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury
Chiba T, Cerqueira DM, Li Y, Bodnar AJ, Mukherjee E, Pfister K, Phua YL, Shaikh K, Sanders BT, Hemker SL, Pagano PJ, Wu YL, Ho J, Sims-Lucas S. J Am Soc Nephrol. 2021 Jan 29:ASN.2020050717. Pubmed
Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p.
Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender I, Haller H, Kistler AD, Dueck A, Engelhardt S, Thum T, Mueller TF, WĂ¼thrich RP, Lorenzen JM. J Am Soc Nephrol. 2021 Feb;32(2):323-341. Pubmed
Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH. Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. Pubmed
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption
Mondala PK, Vora AA, Zhou T, Lazzari E, Ladel L, Luo X, Kim Y, Costello C, MacLeod AR, Jamieson CHM, Crews LA. Cell Stem Cell. 2021 Jan 20:S1934-5909(20)30601-9. Pubmed
Facts about COVID-19 mRNA Vaccines and the Decades of Research That Went into Creating Them
Posted: February 11, 2021 | Updated: October 8, 2021 Despite the global threat of COVID-19, mRNA vaccines, which are highly effective at preventing COVID-19 illness and have passed rigorous safety standards, have been met with skepticism by many people. This suspicion is due in ...
