Reversing a Model of Parkinson’s Disease With in Situ Converted Nigral Neurons
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. Nature. 2020 Jun;582(7813):550-556. Joint First Authors Dr. Hao Qian Parkinson’s ...
Therapeutic siRNA: state of the art
Hu B, Zhong L, Weng Y, Peng L, Huang Y, Zhao Y, Liang XJ. Signal Transduct Target Ther. 2020 Jun 19;5(1):101. Pubmed
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
Debacker AJ, Voutila J, Catley M, Blakey D, Habib N. Mol Ther. 2020 Jun 17:S1525-0016(20)30305-1. Pubmed
Phosphorothioate modified oligonucleotide-protein interactions
Crooke ST, Vickers TA, Liang XH. Nucleic Acids Res. 2020 Jun 4;48(10):5235-5253. Pubmed
Rational design of aptamer switches with programmable pH response
Thompson IAP, Zheng L, Eisenstein M, Soh HT. Nat Commun. 2020 Jun 10;11(1):2946. Pubmed
Determination of RNA structural diversity and its role in HIV-1 RNA splicing
Tomezsko PJ, Corbin VDA, Gupta P, Swaminathan H, Glasgow M, Persad S, Edwards MD, Mcintosh L, Papenfuss AT, Emery A, Swanstrom R, Zang T, Lan TCT, Bieniasz P, Kuritzkes DR, Tsibris A, Rouskin S. Nature. 2020 Jun;582(7812):438-442. Pubmed
Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy
Lavenniah A, Luu TDA, Li YP, Lim TB, Jiang J, Ackers-Johnson M, Foo RS. Mol Ther. 2020 Jun 3;28(6):1506-1517. Pubmed
Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial
Loomba R, Morgan E, Watts L, Xia S, Hannan LA, Geary RS, Baker BF, Bhanot S. Lancet Gastroenterol Hepatol. 2020 Jun 15:S2468-1253(20)30186-2. Pubmed
Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria
Balwani M, Sardh E, Ventura P, PeirĂ³ PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder ...
POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices
Thayer MB, Humphreys SC, Chung KS, Lade JM, Cook KD, Rock BM. Sci Rep. 2020 Jun 26;10(1):10425. Pubmed