Delivery of Macromolecular Therapeutics: Tackling a Billion Year Old Barrier
Presenter:Â Steven Dowdy (UCSD School of Medicine) Date:Â December 17, 2019 Description: All macromolecular therapeutics, including ASOs, siRNAs, peptides, proteins, CRISPR, mRNA and non-viral DNA vectors, are taken up into cells by endocytosis. However, <1% to none of the endocytosed therapeutic cargo escapes into the cytoplasm ...
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