EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis
Zhao Y, Ding L, Wang D, Ye Z, He Y, Ma L, Zhu R, Pan Y, Wu Q, Pang K, Hou X, Weroha SJ, Han C, Coleman R, Coleman I, Karnes RJ, Zhang J, Nelson PS, Wang L, Huang H. EMBO J. 2019 Feb 5. ...
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown
Clayton EL, Milioto C, Muralidharan B, Norona FE, Edgar JR, Soriano A, Jafar-Nejad P, Rigo F, Collinge J, Isaacs AM. Brain. 2018 Dec 1;141(12):3428-3442. PubMed
Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
Gaus HJ, Gupta R, Chappell AE, Østergaard ME, Swayze EE, Seth PP. Nucleic Acids Res. 2018 Dec 19. PubMed
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease
Cansby E, Nuñez-Durán E, Magnusson E, Amrutkar M, Booten SL, Kulkarni NM, Svensson LT, Borén J, Marschall HU, Aghajan M, Mahlapuu M. Cell Mol Gastroenterol Hepatol. 2018 Dec 19. PubMed
WAKMAR2, A Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines
Herter EK, Li D, Toma MA, Vij M, Li X, Visscher D, Wang A, Chu T, Sommar P, Blomqvist L, Berglund D, Ståhle M, Wikstrom JD, Xu Landén N. J Invest Dermatol. 2018 Dec 27. pii: S0022-202X(18)01301-5. PubMed
Next-generation PNA chimeras exhibit high affinity and potent gene silencing
Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts J. Biochemistry. 2018 Dec 6. PubMed
Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides
Wang S, Allen N, Liang XH, Crooke ST. Mol Ther Nucleic Acids. 2018 Dec 7;13:686-698. PubMed
Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice
Kim TW, Papagiannis CN, Zwick LS, Engelhardt JA, Hoffmaster CM, Post NM, Matson JE, Hsiao JA, Burel SA, Henry SP. Toxicol Pathol. 2018 Dec 25:192623318813143. PubMed
Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells
Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S, Lopez R, Pradhan K, Giricz O, Ravipati G, Wong LF, Cole S, Bhagat TD, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan VJ, Wickrema A, Ye BH, Frank DA, Pellagatti A, Boultwood ...
Protein production is an early biomarker for RNA-targeted therapies
Self WK, Schoch KM, Alex J, Barthélemy N, Bollinger JG, Sato C, Cole T, Kordasiewicz HB, Swayze E, Bateman RJ, Miller TM. Ann Clin Transl Neurol. 2018 Oct 14;5(12):1492-1504. PubMed
