Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes
Kanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, Heinecke JW, Bornfeldt KE. J Clin Invest. 2019 Jul 11;130. PubMed
The nuclear concentration required for antisense oligonucleotide activity in myotonic dystrophy cells
van der Bent ML, Paulino da Silva Filho O, Willemse M, Hällbrink M, Wansink DG, Brock R. FASEB J. 2019 Jul 16 PubMed
Steric Inhibition of 5′ UTR Regulatory Elements Results in Upregulation of Human CFTR
Sasaki S, Sun R, Bui HH, Crosby JR, Monia BP, Guo S. Mol Ther. 2019 Jul 12. pii: S1525-0016(19)30312-0. PubMed
Antisense oligonucleotides extend survival of prion-infected mice
Raymond GJ, Zhao HT, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O'Keefe R, Lubke LL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM. JCI ...
Assay Determination by Mass Spectrometry for Oligonucleotide Therapeutics
Madsen M, Roussis S, Schniepp E, Rentel C, Capaldi D. Rapid Commun Mass Spectrom. 2019 Jul 6. PubMed
Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models
Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR. Mol Ther. 2019 Jun 29. pii: S1525-0016(19)30304-1. PubMed
Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species
Post N, Yu R, Greenlee S, Gaus H, Hurh E, Matson J, Wang Y. Drug Metab Dispos. 2019 Jul 26. PubMed
Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice
Aghajan M, Booten SL, Althage M, Hart CE, Ericsson A, Maxvall I, Ochaba J, Menschik-Lundin A, Hartleib J, Kuntz S, Gattis D, Ahlström C, Watt AT, Engelhardt JA, Monia BP, Magnone MC, Guo S. JCI Insight. 2019 Jun 20;4(12). PubMed
Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington’s Disease
Imbert M, Blandel F, Leumann C, Garcia L, Goyenvalle A. Nucleic Acid Ther. 2019 Jun 11. PubMed
Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells
Wang S, Allen N, Prakash TP, Liang XH, Crooke ST. Nucleic Acid Ther. 2019 Jun 3. PubMed
