Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides
de Bruin D, Bossert N, Aartsma-Rus A, Bouwmeester D. J Nanobiotechnology. 2018 Apr 6;16(1):37. PubMed
Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents
Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT. Diabetologia. 2018 Mar 1. PubMed
Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides
Wang S, Allen N, Vickers TA, Revenko AS, Sun H, Liang XH, Crooke ST. Nucleic Acids Res. 2018 Mar 5. PubMed
Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo
Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T. Sci Rep. 2018 Mar 12;8(1):4377. PubMed
A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides
Dieckmann A, Hagedorn PH, Burki Y, Brügmann C, Berrera M, Ebeling M, Singer T, Schuler F. MolTher Nucleic Acids. 2018 Mar 2;10:45-54. PubMed
Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs’ Dystrophy
Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV. Hum Mol Genet. 2018 Jan 8. PubMed
Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides
Wolfe JM, Fadzen CM, Holden RL, Yao M, Hanson GJ, Pentelute B. Angew Chem Int Ed Engl. 2018 Feb 25. PubMed
Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes
Digenio A, Pham NC, Watts LM, Morgan ES, Jung SW, Baker BF, Geary RS, Bhanot S. Diabetes Care. 2018 Feb 9. pii: dc172132. PubMed
PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models
Zhao HT, Damle S, Ikeda-Lee K, Kuntz S, Li J, Mohan A, Kim A, Hung G, Scheideler MA, Scherer SS, Svaren J, Swayze EE, Kordasiewicz HB. J Clin Invest. 2018 Jan 2;128(1):359-368. PubMed
(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis
Ren L, Sun Y, Lu H, Ye D, Han L, Wang N, Daugherty A, Li F, Wang M, Su F, Tao W, Sun J, Zelcer N, Mullick AE, Danser AJ, Jiang Y, He Y, Ruan X, Lu X. Circ Res. 2018 Jan 4. PubMed
