Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties
Papargyri N, Pontoppidan M, Andersen MR, Koch T, Hagedorn PH. Mol Ther Nucleic Acids. 2020 Mar 6;19:706-717. PubMed
Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy
Watt AT, Swayze G, Swayze EE, Freier SM. Nucleic Acid Ther. 2020 Mar 3. PubMed
Origins of the increased affinity of phosphorothioate-modified therapeutic nucleic acids for proteins
Hyjek-SkÅ‚adanowska M, Vickers T, NapiĂ³rkowska A, Anderson B, Tanowitz M, Crooke ST, Liang XH, Seth PP, Nowotny M. J Am Chem Soc. 2020 Mar 23. PubMed
Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice
Chappell AE, Gaus HJ, Berdeja A, Gupta R, Jo M, Prakash TP, Oestergaard M, Swayze EE, Seth PP. Nucleic Acids Res. 2020 Mar 17. PubMed
Delivery of Antisense Oligonucleotides to the Cornea
Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV. Nucleic Acid Ther. 2020 Mar 23. PubMed
Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis
Liu H, Kang RS, Bagnowski K, Yu JM, Radecki S, Daniel WL, Anderson BR, Nallagatla S, Schook A, Agarwal R, Giljohann DA, Paller AS. J Invest Dermatol. 2020 Feb;140(2):435-444.e4. PubMed
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis
Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. Nat Neurosci. 2020 Feb 17. PubMed
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes
Eaton JD, Francis L, Davidson L, West S. Genes Dev. 2020 Jan 1;34(1-2):132-145. PubMed
Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence
Haemmig S, Yang D, Sun X, Das D, Ghaffari S, Molinaro R, Chen L, Deng Y, Freeman D, Moullan N, Tesmenitsky Y, Wara AKMK, Simion V, Shvartz E, Lee JF, Yang T, Sukova G, Marto JA, Stone PH, Lee WL, Auwerx J, Libby P, Feinberg ...
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, BĂ¼ning H, Yang L, Cao ...