CRISPR-SKIP: programmable gene splicing with single base editors
Gapinske M, Luu A, Winter J, Woods WS, Kostan KA, Shiva N, Song JS, Perez-Pinera P. Genome Biol. 2018 Aug 15;19(1):107. PubMed
TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models
Fernández G, Moraga A, Cuartero MI, García-Culebras A, Peña-Martínez C, Pradillo JM, Hernández-Jiménez M, Sacristán S, Ayuso MI, Gonzalo-Gobernado R, Fernández-López D, Martín ME, Moro MA, González VM, Lizasoain I. Mol Ther. 2018 Aug 1;26(8):2047-2059. PubMed
Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment
Lei Y, He X, Tang J, Shi H, He D, Yan L, Liu J, Zeng Y, Wang K. Chem Commun (Camb). 2018 Aug 23. PubMed
Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity
Schrand B, Clark E, Levay A, Capote AR, Martinez O, Brenneman R, Castro I, Gilboa E. Nat Commun. 2018 Aug 22;9(1):3348. PubMed
Unlocking P(V): Reagents for chiral phosphorothioate synthesis
Knouse KW, deGruyter JN, Schmidt MA, Zheng B, Vantourout JC, Kingston C, Mercer SE, Mcdonald IM, Olson RE, Zhu Y, Hang C, Zhu J, Yuan C, Wang Q, Park P, Eastgate MD, Baran PS. Science. 2018 Aug 2. PubMed
Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M. Nucleic Acids Res. 2018 Aug 11. PubMed
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier
Godinho BMDC, Henninger N, Bouley J, Alterman JF, Haraszti RA, Gilbert JW, Sapp E, Coles AH, Biscans A, Nikan M, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Mol Ther. 2018 Aug 8. pii: S1525-0016(18)30376-9. PubMed
Titanium implant functionalized with antimiR-138 delivered cell sheet for enhanced peri-implant bone formation and vascularization
Yan J, Chang B, Hu X, Cao C, Zhao L, Zhang Y. Mater Sci Eng C Mater Biol Appl. 2018 Aug 1;89:52-64. PubMed
Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles
Haraszti RA, Miller R, Didiot MC, Biscans A, Alterman JF, Hassler MR, Roux L, Echeverria D, Sapp E, DiFiglia M, Aronin N, Khvorova A. Mol Ther. 2018 Aug 1;26(8):1973-1982. PubMed
Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides
Kasuya T, Kugimiya A. Nucleic Acid Ther. 2018 Aug 10. PubMed
