Antisense Drug Discovery and Development Technology Considered in a Pharmacological Context
Crooke ST, Liang XH, Crooke RM, Baker BF, Geary RS. Biochem Pharmacol. 2020 Aug 12:114196. Pubmed
Maximizing transcription of nucleic acids with efficient T7 promoters
Conrad T, Plumbom I, Alcobendas M, Vidal R, Sauer S. Commun Biol. 2020 Aug 14;3(1):439. Pubmed
Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment
Hewitt SL, Bailey D, Zielinski J, Apte A, Musenge F, Karp R, Burke S, Garcon F, Mishra A, Gurumurthy S, Watkins A, Arnold K, Moynihan J, Clancy-Thompson E, Mulgrew K, Adjei G, Deschler K, Potz D, Moody G, Leinster DA, Novick S, Sulikowski M, Bagnall ...
Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults.
Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil K, Raabe V, Bailey R, Swanson KA, Li P, Koury K, Kalina W, Cooper D, Fontes-Garfias C, Shi PY, TĂ¼reci Ă–, Tompkins KR, Walsh EE, Frenck R, Falsey AR, Dormitzer PR, Gruber ...
Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia
Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, Hurh E, Kingsbury J, Bartlett VJ, Figueroa AL, Piscitelli P, Singleton W, Witztum JL, Geary RS, Tsimikas S, St L O'Dea L. Eur Heart J. 2020 Aug 29:ehaa689. Pubmed
Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system.
Sullivan JM, Mazur C, Wolf DA, Horky L, Currier N, Fitzsimmons B, Hesterman J, Pauplis R, Haller S, Powers B, Tayefeh L, DeBrosse-Serra B, Hoppin J, Kordasiewicz H, Swayze EE, Verma A. J Transl Med. 2020 Aug 8;18(1):309. Pubmed
The dose threshold for nanoparticle tumour delivery
Ouyang B, Poon W, Zhang YN, Lin ZP, Kingston BR, Tavares AJ, Zhang Y, Chen J, Valic MS, Syed AM, MacMillan P, Couture-Senécal J, Zheng G, Chan WCW. Nat Mater. 2020 Aug 10. Pubmed
Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras
Langner HK, Jastrzebska K, Caruthers MH. J Am Chem Soc. 2020 Aug 31. Pubmed
A short de novo synthesis of nucleoside analogs
Meanwell M, Silverman SM, Lehmann J, Adluri B, Wang Y, Cohen R, Campeau LC, Britton R. Science. 2020 Aug 7;369(6504):725-730. Pubmed
Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy
De La Fuente A, Zilio S, Caroli J, Van Simaeys D, Mazza EMC, Ince TA, Bronte V, Bicciato S, Weed DT, Serafini P. Sci Transl Med. 2020 Jun 17;12(548):eaav9760. Pubmed