2015 OTS Poster Award Winners
Umar Burki, Newcastle University – Poster #009In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino OligonucleotidesAlexandre Debacker, University of Southampton – Poster #020Optimized DNA-PNA chimeras for silencing structured RNAsAnna Dysko, University of Oxford – Poster #026Synthesis of Modified Oligonucleotides Containing Triazole BackbonesEllen Gyssels, University ...
Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents
Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT. Diabetologia. 2018 Mar 1. PubMed
Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides
Wang S, Allen N, Vickers TA, Revenko AS, Sun H, Liang XH, Crooke ST. Nucleic Acids Res. 2018 Mar 5. PubMed
Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. MolTher. 2018 Mar 7;26(3):708-717. PubMed
RNA activating-double stranded RNA targeting flt-1 promoter inhibits endothelial cell proliferation through solubleFLT-1 upregulation
Choi S, Uehara H, Wu Y, Das S, Zhang X, Archer B, Carroll L, Ambati BK. PLoS One. 2018 Mar 6;13(3):e0193590. PubMed
Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer
Reebye V, Huang KW, Lin V, Jarvis S, Cutilas P, Dorman S, Ciriello S, Andrikakou P, Voutila J, Saetrom P, Mintz PJ, Reccia I, Rossi JJ, Huber H, Habib R, Kostomitsopoulos N, Blakey DC, Habib NA. Oncogene. 2018 Mar 7. PubMed
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model
Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. MolTher. 2018 Mar 7;26(3):793-800. PubMed
Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis
Guo J, Cai H, Liu X, Zheng J, Liu Y, Gong W, Chen J, Xi Z, Xue Y. MolTher Nucleic Acids. 2018 Mar 2;10:170-186. PubMed
The lncRNA Plscr4 Controls Cardiac Hypertrophy by RegulatingmiR-214
Lv L, Li T, Li X, Xu C, Liu Q, Jiang H, Li Y, Liu Y, Yan H, Huang Q, Zhou Y, Zhang M, Shan H, Liang H. MolTher Nucleic Acids. 2018 Mar 2;10:387-397. PubMed
Loss of long non-coding RNA ROCR facilitates endogenous cardiac regeneration
Li X, He X, Wang H, Li M, Huang S, Chen G, Jing Y, Wang S, Chen Y, Liao W, Liao Y, Bin J. Cardiovasc Res. 2018 Mar 23. PubMed
