Design of Exon Skipping Oligonucleotides
Presenter: Annemieke Aartsma-Rus, PhD, Leiden University Medical Center Date: 20 February 2018 Description: Antisense-mediated splicing modulation utilizes antisense oligonucleotides (ASOs) to manipulate the splicing by sterically blocking the binding of splicing factors to pre-mRNA transcripts. While in industry often oligo walks are used to ...
Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides
Bailey JK, Shen W, Liang XH, Crooke ST. Nucleic Acids Res. 2017 Oct 13;45(18):10649-10671. Dr. Jeffrey Bailey This paper is the latest in a series of publications from Stanley Crooke’s lab at Ionis investigating the interactions between phosphorothioate antisense oligonucleotides and intracellular proteins. ...
Interview with Vadim Y Dudkin, PhD
I first became exposed to oligonucleotide delivery while at Merck upon the acquisition of Sirna in 2006. Part of my work at the time involved glyco
