A self-catabolic multifunctional DNAzyme nanosponge for programmable drug delivery and efficient gene silencing
Wang J, Yu S, Wu Q, Gong X, He S, Shang J, Liu X, Wang F. Angew Chem Int Ed Engl. 2021 Feb 18. Pubmed
Centyrin ligands for extrahepatic delivery of siRNA.
Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Mol Ther. 2021 Feb 15:S1525-0016(21)00082-4. Pubmed
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell
Knerr L, Prakash TP, Lee R, Drury Iii WJ, Nikan M, Fu W, Pirie E, Maria L, Valeur E, Hayen A, Ă–lwegĂ¥rd-Halvarsson M, Broddefalk J, Ă„mmälä C, Ă˜stergaard ME, Meuller J, Sundström L, Andersson P, JanzĂ©n D, Jansson-Löfmark R, Seth PP, Andersson S. J Am ...
siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M. Nucleic Acids Res. 2021 Feb 12 Pubmed
Perspectives on the Designation of Oligonucleotide Starting Materials
Kiesman WF, McPherson AK, Diorazio LJ, Van den Bergh L, Smith PD, Northall JM, Fettes A, Wang T, Mehlmann M, Raza S, Held G. Nucleic Acid Ther. 2021 Feb 2. Pubmed
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Vasquez G, Freestone GC, Wan WB, Low A, De Hoyos CL, Yu J, Prakash TP, Ǿstergaard ME, Liang XH, Crooke ST, Swayze EE, Migawa MT, Seth PP. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. Pubmed
Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes
Han D, Miao Y, Gao Q, Mao M, Zhang C, Yang L, Yang Y. Angew Chem Int Ed Engl. 2021 Feb 25 Pubmed
Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents
Blanchard EL, Vanover D, Bawage SS, Tiwari PM, Rotolo L, Beyersdorf J, Peck HE, Bruno NC, Hincapie R, Michel F, Murray J, Sadhwani H, Vanderheyden B, Finn MG, Brinton MA, Lafontaine ER, Hogan RJ, Zurla C, Santangelo PJ. Nat Biotechnol. 2021 Feb 3. Pubmed
Systemic delivery of antagomirs during blood brain barrier disruption is disease-modifying in experimental epilepsy
Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, RĂ¼ber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC. Mol Ther. 2021 Feb 17:S1525-0016(21)00088-5. Pubmed
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
Zheng F, Chen J, Zhang X, Wang Z, Chen J, Lin X, Huang H, Fu W, Liang J, Wu W, Li B, Yao H, Hu H, Song E. Nat Commun. 2021 Feb 26;12(1):1341. Pubmed