Biochemical Methods to Image and Analyze RNA Localization: from One to Many
Li Y, Ke K, Spitale RC. Biochemistry. 2018 Nov 16. PubMed
Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches
Qian X, Zhao J, Yeung PY, Zhang QC, Kwok CK. Trends Biochem Sci. 2018 Nov 17. pii: S0968-0004(18)30197-X. PubMed
Pitfalls and problems of miRNA expression analysis
Presenter: Michela Denti PhD, University of Trento, Italy Prof. Denti has an unavoidable commitment that came up on short notice and has arranged for Simone Detassis from her lab to give the webinar in her place. Date: February 12, 2019 Description: microRNAs are intensively ...
Guidelines for Experiments using Antisense Oligonucleotides and Double-Stranded RNAs
Presenter: David Corey PhD, University of Texas, USA Date: 6 December 2018 Description: After decades of research and development, synthetic nucleic acids are beginning to enjoy significant success in the clinic. Approved drugs have increased interest in the field and many basic research studies ...
2018 OTS Lifetime Achievement Award Winner Marvin H. Caruthers
Marvin H. Caruthers Distinguished Professor of Chemistry University of Colorado Boulder, Colorado Marvin H. Caruthers is a Distinguished Professor of Biochemistry and Chemistry at the University of Colorado, Boulder. A Guggenheim Fellow, Dr. Caruthers received his B.S. in Chemistry from Iowa State University, his Ph.D. ...
Interview with Pad Chivukula, PhD
My mentor helped me to see the potential of pharmaceutical research on our society.
2018 OTS Poster Award Winners
001 Bruno Godinho, University of Massachusetts Medical School Neuroactive siRNA Scaffold Enables Broad Distribution and Robust Gene Silencing Throughout the Central Nervous System: Preclinical Studies in Large Mammals 002 Julia Alterman, University of Massachusetts Medical School Potent and long-term RNA interference-based silencing of huntingtin expression ...
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease
Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9687-E9696. PubMed
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Southwell AL, Kordasiewicz HB, Langbehn D, Skotte NH, Parsons MP, Villanueva EB, Caron NS, Østergaard ME, Anderson LM, Xie Y, Cengio LD, Findlay-Black H, Doty CN, Fitsimmons B, Swayze EE, Seth PP, Raymond LA, Frank Bennett C, Hayden MR. Sci Transl Med. 2018 Oct 3;10(461). ...
Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7
Niu C, Prakash TP, Kim A, Quach JL, Huryn LA, Yang Y, Lopez E, Jazayeri A, Hung G, Sopher BL, Brooks BP, Swayze EE, Bennett CF, La Spada AR. Sci Transl Med. 2018 Oct 31;10(465). PubMed
