Presenter: Donald H. Burke/David Porciani, University of Missouri, USA
Date: July 25, 2019
Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs (<15 kDa, 19-21 nt/strand) to large, functional RNA payloads (50-80 kDa, 175-250 nt). In this webinar we will discuss the options for linking aptamers to the therapeutic nucleic acid, what to watch out for during this process and how to best confirm specific targeting.