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  • June 20, 2024
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Date: June 27, 2024
Time: 8am PDT / 11am EDT / 5pm CEST

Title: Functional Aptamer Selection for the Low-Complexity Domain of TDP-43 as a Potential Treatment Avenue for ALS

Description: Targeting of TAR-DNA Binding Protein-43 (TDP-43), a protein implicated in both sporadic and familial ALS, offers a promising approach given the scarcity of effective treatments and the potential of nucleic acid therapeutics in neurodegenerative diseases. In this selection, we aim to select DNA aptamers that specifically bind to the low-complexity domain of TDP-43, potentially inhibiting its aggregation, and blocking its mislocalization from the nucleus to the cytoplasm. By preventing TDP-43 aggregation and mislocalization, these DNA aptamers aim to provide a novel therapeutic strategy for treating ALS, striving to mitigate the progression of the disease and eventually improve patient outcomes.

Speaker:

Daniel Knight
Carleton University, PhD Candidate

Title: Characterization of Acute Myeloid Leukemia specific -DNA aptamers

Description: Leukemia is a blood cancer found in both blood and bone marrow. Acute Myeloid Leukemia (AML) is one of the main subtypes of leukemia that stems from mutations in myeloid progenitor cells and blasts. Aptamers are short single-stranded DNA or RNA oligonucleotides selected by a process called systematic evolution of ligands by exponential enrichment (SELEX). The main objective of my PhD project is to develop an aptamer-based protocol for identifying AML cell biomarkers.

Speaker:

Bahareh Hosseinpour
Carleton University, PhD Candidate