Oligonucleotide Therapeutics Society

2021 Basic Paper Of The Year Award – Winners

October 28th, 2021|Categories: Paper of the Year Award, Basic Featured Paper of the Year|

Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or [...]

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