2022 Paper of the Year Award – Basic Research Category
Tetsuya Nagata, Takanori Yokota, et al, Nature Biotechnology (2021). https://doi.org/10.1038/s41587-021-00972-x Takanori Yokota, MD, PhD Tokyo Medical and Dental University Biography: Dr. Yokota graduated from Tokyo Medical and Dental University in 1984 and completed his Residency and Fellowship in Musashino Red Cross Hospital in ...
2022 Paper of the Year Award – Basic Research Category
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Kirk M. Brown, Martin A. Maier, Vasant Jadhav, et al, Nature Biotechnology (2022). https://doi.org/10.1038/s41587-022-01334-x Vasant Jadhav, PhD Alnylam Pharmaceuticals Biography: Vasant Jadhav is a Senior Vice President of Research at Alnylam Pharmaceuticals, where he ...
2021 Late Discovery Paper Of The Year Award – Winners
An mRNA Vaccine Against SARS-CoV-2 – Preliminary Report Phase I/II study of COVID-19 RNA vaccine BNT 162b1 in adults The need for platforms to develop vaccines rapidly and efficiently was clearly highlighted by the Covid-19 pandemic. The first vaccine against SARS-CoV-2 was approved only ...
2021 Basic Paper Of The Year Award – Winners
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or ...
Directed RNase H cleavage of nascent transcripts causes transcription termination
Lai F, Damle SS, Ling KK, Rigo F Read More
Inclisiran for the treatment of heterozygous familial hyper-cholesterolemia (Raal et al., 2020)
Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. Lee JS, Mendell JT. Read More
Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination.
Lee JS, Mendell JT. Mol Cell. 2020 Jan 2. pii: S1097-2765(19)30924-4. PubMed
2018 Paper of the Year Award Winner: Alejandra Gonzalez-Duarte, MD
Dr. Alejandra Gonzalez-Duarte, MDNational Institute of Medical Sciences and Nutrition–Salvador Zubiran, MexicoTalk Title: Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin AmyloidosisA.Gonzalez‑Duarte1, D. Adams2, W.D. O’Riordan3, C.-C. Yang4, M. Ueda5, A.V. Kristen6, I. Tournev7, H.H. Schmidt8, T. Coelho9, J.L. Berk10, K.-P. Lin11, G. Vita12, S. Attarian13, ...
2017 Paper of the Year Award Winner: Richard Finkel, MD
Richard Finkel, MD Nemours Children’s Hospital Talk Title: Treatment of Infantile-onset Spinal Muscular Atrophy with Nusinersen: a Phase 2, Open-label, Dose-escalation Study Biography: Richard S. Finkel, MD is Professor of Neurology at the University of Central Florida School of Medicine, and Chief, Division of Neurology ...
2016 Paper of the Year Award Winner: Victor Serebrov, PhD
Authors: William “Wes” Salomon, Samson Jolly, Victor Serebrov, Melissa Moore, Phillip Zamore – RNA Therapeutics Institute, University of Massachusetts Medical Center Presenter: Victor Serebrov, PhD RNA Therapeutics Institute, University of Massachusetts Medical Center Talk Title: Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of ...
