Oligonucleotide Therapeutics Society

2021 Basic Paper Of The Year Award – Winners

October 28th, 2021|Categories: Paper of the Year Award, Basic Featured Paper of the Year|

Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or [...]

Inclisiran for the treatment of heterozygous familial hyper-cholesterolemia (Raal et al., 2020)

August 18th, 2020|Categories: Late Discovery Featured Paper of the Year, Paper of the Year Award|

Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. Lee JS, Mendell JT. Read More

2018 Paper of the Year Award Winner: Alejandra Gonzalez-Duarte, MD

September 20th, 2018|Categories: Paper of the Year Award|

Dr. Alejandra Gonzalez-Duarte, MDNational Institute of Medical Sciences and Nutrition–Salvador Zubiran, MexicoTalk Title: Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin AmyloidosisA.Gonzalez‑Duarte1, D. Adams2, W.D. O’Riordan3, C.-C. Yang4, M. Ueda5, A.V. Kristen6, I. Tournev7, H.H. Schmidt8, T. Coelho9, J.L. Berk10, K.-P. Lin11, G. Vita12, S. Attarian13, [...]

2017 Paper of the Year Award Winner: Richard Finkel, MD

April 15th, 2017|Categories: Paper of the Year Award|

Richard Finkel, MD Nemours Children’s Hospital Talk Title: Treatment of Infantile-onset Spinal Muscular Atrophy with Nusinersen: a Phase 2, Open-label, Dose-escalation Study Biography: Richard S. Finkel, MD is Professor of Neurology at the University of Central Florida School of Medicine, and Chief, Division of Neurology [...]

2016 Paper of the Year Award Winner: Victor Serebrov, PhD

April 15th, 2016|Categories: Paper of the Year Award|

Authors: William “Wes” Salomon, Samson Jolly, Victor Serebrov, Melissa Moore, Phillip Zamore – RNA Therapeutics Institute, University of Massachusetts Medical Center Presenter: Victor Serebrov, PhD RNA Therapeutics Institute, University of Massachusetts Medical Center Talk Title: Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of [...]

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