2022 Paper of the Year Award – Basic Research Category

September 19th, 2022|Categories: Basic Featured Paper of the Year, Paper of the Year Award|

Tetsuya Nagata, Takanori Yokota, et al, Nature Biotechnology (2021). https://doi.org/10.1038/s41587-021-00972-x Takanori Yokota, MD, PhD Tokyo Medical and Dental University Biography: Dr. Yokota graduated from Tokyo Medical and Dental University in 1984 and completed his Residency and Fellowship in Musashino Red Cross Hospital in ...

2022 Paper of the Year Award – Basic Research Category

September 19th, 2022|Categories: Basic Featured Paper of the Year, Paper of the Year Award|

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Kirk M. Brown, Martin A. Maier, Vasant Jadhav, et al, Nature Biotechnology (2022). https://doi.org/10.1038/s41587-022-01334-x Vasant Jadhav, PhD Alnylam Pharmaceuticals Biography: Vasant Jadhav is a Senior Vice President of Research at Alnylam Pharmaceuticals, where he ...

2021 Basic Paper Of The Year Award – Winners

October 28th, 2021|Categories: Paper of the Year Award, Basic Featured Paper of the Year|

Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or ...

Inclisiran for the treatment of heterozygous familial hyper-cholesterolemia (Raal et al., 2020)

August 18th, 2020|Categories: Late Discovery Featured Paper of the Year, Paper of the Year Award|

Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. Lee JS, Mendell JT. Read More

2018 Paper of the Year Award Winner: Alejandra Gonzalez-Duarte, MD

September 20th, 2018|Categories: Paper of the Year Award|

Dr. Alejandra Gonzalez-Duarte, MDNational Institute of Medical Sciences and Nutrition–Salvador Zubiran, MexicoTalk Title: Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin AmyloidosisA.Gonzalez‑Duarte1, D. Adams2, W.D. O’Riordan3, C.-C. Yang4, M. Ueda5, A.V. Kristen6, I. Tournev7, H.H. Schmidt8, T. Coelho9, J.L. Berk10, K.-P. Lin11, G. Vita12, S. Attarian13, ...

2017 Paper of the Year Award Winner: Richard Finkel, MD

April 15th, 2017|Categories: Paper of the Year Award|

Richard Finkel, MD Nemours Children’s Hospital Talk Title: Treatment of Infantile-onset Spinal Muscular Atrophy with Nusinersen: a Phase 2, Open-label, Dose-escalation Study Biography: Richard S. Finkel, MD is Professor of Neurology at the University of Central Florida School of Medicine, and Chief, Division of Neurology ...

2016 Paper of the Year Award Winner: Victor Serebrov, PhD

April 15th, 2016|Categories: Paper of the Year Award|

Authors: William “Wes” Salomon, Samson Jolly, Victor Serebrov, Melissa Moore, Phillip Zamore – RNA Therapeutics Institute, University of Massachusetts Medical Center Presenter: Victor Serebrov, PhD RNA Therapeutics Institute, University of Massachusetts Medical Center Talk Title: Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of ...

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