2024 Paper of the Year – Basic Research category
Dr. Mikyung Yu, Ph.D. Alnylam Pharmaceuticals Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates 2024 Paper of the Year – Basic Research category https://pubmed.ncbi.nlm.nih.gov/38742636/ Biography: Mikyung Yu, Ph.D., is a Principal Scientist in Research at Alnylam Pharmaceuticals. Dr. Yu led the ...
2022 Paper of the Year Award – Basic Research Category
Tetsuya Nagata, Takanori Yokota, et al, Nature Biotechnology (2021). https://doi.org/10.1038/s41587-021-00972-x Takanori Yokota, MD, PhD Tokyo Medical and Dental University Biography: Dr. Yokota graduated from Tokyo Medical and Dental University in 1984 and completed his Residency and Fellowship in Musashino Red Cross Hospital ...
2022 Paper of the Year Award – Basic Research Category
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Kirk M. Brown, Martin A. Maier, Vasant Jadhav, et al, Nature Biotechnology (2022). https://doi.org/10.1038/s41587-022-01334-x Vasant Jadhav, PhD Alnylam Pharmaceuticals Biography: Vasant Jadhav is a Senior Vice President of Research at Alnylam Pharmaceuticals, where he ...
2021 Basic Paper Of The Year Award – Winners
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or ...
Directed RNase H cleavage of nascent transcripts causes transcription termination
Lai F, Damle SS, Ling KK, Rigo F Read More
Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination.
Lee JS, Mendell JT. Mol Cell. 2020 Jan 2. pii: S1097-2765(19)30924-4. PubMed
