Site-specific detection of mutagenic DNA damage with an artificial nucleotide

Time: 11am – 12pm EST
Date: October 27, 2022

Description:

Incorporating nucleotides with altered structures that are derived synthetically is a strategy that has been used widely to interrogate biological processes involving DNA. Particularly, synthetic nucleotides able to stabilize damaged over undamaged templates have been employed as probes for DNA damage detection and as mechanistic tools. In this webinar, Dr. Claudia Aloisi will focus on and present the development of an artificial nucleotide-based method for the detection of a mutagenic DNA adduct in a site-specific manner