Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
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mRNA structural dynamics shape Argonaute-target interactions.
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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
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Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease
Elitt MS, Barbar L, Shick HE, Powers BE, Maeno-Hikichi Y, Madhavan M, Allan KC, Nawash BS, Gevorgyan AS, Hung S, Nevin ZS, Olsen HE, Hitomi M, Schlatzer DM, Zhao HT, Swayze A, LePage DF, Jiang W, Conlon RA, Rigo F, Tesar PJ. Nature. 2020 Jul ...
Interview with Christian Berk, PhD
Christian Berk, Ph.D., ETH Zurich How did you become interested in the field of oligonucleotides? Frankly, I did not know much about RNA therapeutics when I joined Jonathan Hall’s group at ETH Zurich. After finishing my studies, I just knew that I wanted to ...